Kanna
Sceletium tortuosum
Family: Aizoaceae
Kanna is a succulent plant native to South Africa, traditionally used by indigenous San and Khoikhoi peoples for its mood-enhancing properties. The plant contains mesembrine-type alkaloids with unique pharmacological profiles.
Traditional Use
Used for thousands of years by indigenous South African peoples as a mood enhancer, stress reliever, and social facilitator. Traditionally chewed, smoked, or made into teas and tinctures.
Active Compounds
Mechanisms of Action
- Serotonin reuptake inhibition
- PDE4 inhibition
- VMAT2 interaction
- 5-HT receptor modulation
Applications
Clinical Status
Clinical trials ongoing. Our KAN-301 standardised extract is in preclinical development with promising safety and efficacy data.
Regulatory Notes
Legal in most jurisdictions as a dietary supplement. Increasingly recognised by regulatory bodies as a legitimate botanical ingredient.
Sourcing & Sustainability
Sourced through ethical partnerships with indigenous communities in South Africa, ensuring fair benefit sharing and sustainable cultivation practices.
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