Our Scientific Approach
Bridging traditional ethnobotanical knowledge with pharmaceutical-grade analytical rigor through a systematic, evidence-based research methodology.
Four-Stage Research Pipeline
Each compound progresses through our rigorous validation framework before reaching commercialisation.
Ethnobotanical Survey
Systematic documentation of traditional uses and indigenous knowledge systems across our sourcing regions.
Key Activities
- Collaborative partnerships with indigenous communities and traditional healers
- Documentation of historical uses, preparation methods, and dosage practices
- Cultural context analysis and intellectual property considerations
- Identification of candidate plants based on traditional efficacy claims
Phytochemical Screening
Identification and characterisation of bioactive compounds using advanced analytical chemistry methods.
Key Activities
- High-Performance Liquid Chromatography (HPLC) for compound separation
- Mass Spectrometry (LC-MS/MS) for molecular identification
- Nuclear Magnetic Resonance (NMR) spectroscopy for structural elucidation
- Standardisation protocols for active constituent quantification
Bioassay & Validation
In vitro and in vivo testing to validate mechanisms of action and establish safety profiles.
Key Activities
- Receptor binding studies and enzyme inhibition assays
- Cell-based functional assays for biological activity confirmation
- ADME (Absorption, Distribution, Metabolism, Excretion) profiling
- Preliminary toxicology screening and safety assessment
Clinical Development
Progression through clinical trials with Contract Research Organisation (CRO) partners to establish efficacy and safety.
Key Activities
- Phase I: Safety, tolerability, and pharmacokinetics in healthy volunteers
- Phase II: Proof of concept and dose-ranging studies in target populations
- Phase III: Large-scale efficacy trials for regulatory submission
- Post-market surveillance and pharmacovigilance programs
Analytical Methods
Our partner laboratories employ state-of-the-art analytical instrumentation for comprehensive compound characterisation.
| Method | Application | Sensitivity |
|---|---|---|
| HPLC-UV/DAD | Quantitative analysis of major constituents | ppm to ppb range |
| LC-MS/MS | Trace compound identification and metabolite profiling | ppb to ppt range |
| GC-MS | Volatile compound analysis and terpene profiling | ppm range |
| NMR Spectroscopy | Structural confirmation and purity assessment | High specificity |
| ICP-MS | Heavy metal and contaminant screening | ppb range |
Regulatory Compliance
All research activities are conducted in accordance with international quality standards and regulatory guidelines, ensuring data integrity and reproducibility.
GMP Compliance
Good Manufacturing Practice certification across partner facilities
ISO 17025
Accredited analytical testing laboratory standards
ICH Guidelines
International Council for Harmonisation quality guidelines
GACP
Good Agricultural and Collection Practices for botanical sourcing
Data Management & Integrity
Our research data management systems ensure complete traceability, version control, and compliance with regulatory requirements for Good Laboratory Practice (GLP) and Good Clinical Practice (GCP).
Electronic Lab Notebooks
Secure, timestamped documentation of all experimental procedures and observations.
LIMS Integration
Laboratory Information Management Systems for sample tracking and result management.
Data Archival
Long-term storage with audit trails ensuring data integrity for regulatory inspections.
Statistical Analysis
Validated software for experimental design, power analysis, and statistical evaluation.
Collaborate With Us
Interested in partnering on botanical research projects? Our methodology framework is available for collaborative initiatives.
Discuss Research Partnerships