Lion's Mane
Hericium erinaceus
Family: Hericiaceae
Lion's Mane is a distinctive edible and medicinal mushroom recognised for its cascading white spines. It produces unique secondary metabolites — hericenones and erinacines — that are among the few natural compounds known to stimulate nerve growth factor (NGF) synthesis, making it a focus of neurological research.
Traditional Use
Revered in traditional Chinese medicine for centuries as a tonic for the spleen, gut, and mind. Known as 'Hóu Tóu Gū' (monkey head mushroom), it was historically reserved for royalty and used by Buddhist monks to enhance focus during meditation.
Active Compounds
Mechanisms of Action
- Nerve growth factor (NGF) stimulation
- Brain-derived neurotrophic factor (BDNF) upregulation
- Anti-neuroinflammatory activity
- Antioxidant neuroprotection
Applications
Clinical Status
Our LM-401 standardised extract is in Phase I/II clinical development for cognitive support indications. Preliminary data shows promising biomarker outcomes for NGF-related endpoints.
Regulatory Notes
Widely accepted as a food and dietary supplement ingredient across major markets including the USA, EU, and Asia-Pacific. No significant regulatory restrictions in most jurisdictions.
Sourcing & Sustainability
Produced through controlled indoor cultivation at GMP-certified facilities, ensuring consistent potency, purity, and freedom from environmental contaminants. Substrate and growing conditions are optimised for maximum bioactive compound yield.
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