Mitragyna
Mitragyna speciosa
Family: Rubiaceae
Mitragyna speciosa is a tropical evergreen tree native to Southeast Asian rainforests. Its leaves contain a complex alkaloid profile centred on mitragynine and 7-hydroxymitragynine, which interact with opioid and adrenergic receptor systems. The plant is the subject of significant pharmacological research for novel analgesic pathways.
Traditional Use
Used for centuries by agricultural workers and labourers in Thailand and Malaysia as a stimulant at low doses and for pain relief at higher doses. Leaves were traditionally chewed fresh or brewed into a tea to combat fatigue during long working hours.
Active Compounds
Mechanisms of Action
- Partial mu-opioid receptor agonism
- Delta-opioid receptor activity
- Adrenergic receptor modulation
- Serotonergic pathway interaction
Applications
Clinical Status
Early-stage discovery programme. Our MIT-701 compound is under investigation for novel analgesic applications with a focus on understanding structure-activity relationships of key alkaloids.
Regulatory Notes
Regulatory status varies significantly by jurisdiction. Subject to ongoing regulatory review in multiple markets. Our research programme operates in full compliance with applicable national and international regulations.
Sourcing & Sustainability
Sourced from licensed cultivators in Thailand operating under government-approved frameworks, with full chain-of-custody documentation and rigorous quality controls at origin.
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